See How We’ve Delivered Real Results Across Industries with our technology

Microbial Products & Strains

Novel Fermentation Design for Soil Bacteria

We built and optimized a fermentation process for Rubrivivax gelatinosus, successfully evaluated in field trials to identify bacterial viability in soil and assess effects on native microbial communities.

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Enzymes

Our flexible service model allows us to tailor projects across sectors, from single cloning projects to complex end-to-end biotechnology solutions.

Endemic Microorganism & Enzyme Optimization

Alagene uses directed evolution, multi-parameter high-throughput screening, and enzyme production to develop high-performance biological solutions for hazardous soil contaminants.

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2.5 g/l Amylase production

We developed parallel Bacillus subtilis and Pichia pastoris production hosts for secreted α-amylase, using a tiered immunoassay → bioassay → HPLC screening cascade and DOE fermentation to reach ~2.5 g/L in Pichia pastoris and ~1 g/L in Bacillus subtilis.

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100-fold improvement of product yield

Using Design of Experiments (DOE) to optimize fermentation, we substantially increased protein yield from a Pichia pastoris production strain

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Proteins & Peptides

Recombinant Protein Production Platform

A client dependent on a single external supplier needed an in-house recombinant protein expression and purification process. Alagene ruled out a translation-level cause for persistent product-related impurities, traced the issue to a post-translational origin, and delivered a robust protocol at over 70% purity.

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25x Increase in Biomass - Bio-Mimetic Biomaterial Producing Microorganisms

We optimized an industry-oriented fermentation workflow for microorganisms producing bio-mimetic biomaterials, achieving a 25-fold increase in biomass yield through process optimization and DOE.

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Cost-effective downstream processes for peptids

We develop cost-effective downstream processes for peptides

Natural & Functional Biomolecules

From Locked to Editable: Making a Production Antibiotic Strain Engineerable

How we turned a genetically “closed” antibiotic producer into an open engineering platform

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Scalable Bioprocess Development for Specialty Molecules

We optimized microbial production processes for specialty molecule manufacturing

Biosensors & Living Diagnostics

Engineered Biosensor Based on Genetic Circuits

We engineered microbial biosensors capable of detecting target compounds with high sensitivity

Environmental field scientists collecting samples at an industrial site.

Microbial Biosensor for Environmental Monitoring

A four-bioreactor study identified the pH, dissolved oxygen, iron supplementation, and harvest timing that improve bacterial pigment production.

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See How We’ve Delivered Real Results Across Industries with our technology

Microbial Products & Strains

Novel Fermentation Design for Soil Bacteria

Enzymes